6Y8K

Crystal structure of CD137 in complex with the cyclic peptide BCY10916

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (AAA)	Tumor necrosis factor receptor superfamily member 9	polymer	165	17765.1	1	UniProt (Q07011) Pfam (PF00020)	Homo sapiens (Human)	4-1BB ligand receptor,CDw137,T-cell antigen 4-1BB homolog,T-cell antigen ILA
2	B (PPP)	BCY10916	polymer	15	1754.0	1		Homo sapiens
3	C (AAA)	ACETATE ION	non-polymer		59.0	1	Chemie (ACT)
4	D (AAA)	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
5	E, F, G (AAA)	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
6	H (AAA)	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
7	I (PPP)	1,1',1''-(1,3,5-triazinane-1,3,5-triyl)tripropan-1-one	non-polymer		255.3	1	Chemie (29N)
8	J, K (AAA, PPP)	water	water		18.0	30	Chemie (HOH)

Sequence modifications

AAA: 24 - 160 (UniProt: Q07011)

PDB	External Database	Details
Met 4	-	initiating methionine
Val 5	-	expression tag
Ser 6	-	expression tag
Ala 7	-	expression tag
Ile 8	-	expression tag
Val 9	-	expression tag
Leu 10	-	expression tag
Tyr 11	-	expression tag
Val 12	-	expression tag
Leu 13	-	expression tag
Leu 14	-	expression tag
Ala 15	-	expression tag
Ala 16	-	expression tag
Ala 17	-	expression tag
Ala 18	-	expression tag
His 19	-	expression tag
Ser 20	-	expression tag
Ala 21	-	expression tag
Phe 22	-	expression tag
Ala 23	-	expression tag
Ser 121	Cys 121	conflict
Asp 138	Asn 138	conflict
Asp 149	Asn 149	conflict
Gly 161	-	expression tag
Ser 162	-	expression tag
His 163	-	expression tag
His 164	-	expression tag
His 165	-	expression tag
His 166	-	expression tag
His 167	-	expression tag
His 168	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	19519.1
Non-Polymers*	Number of molecules	7
	Total formula weight	687.6
All*	Total formula weight	20206.7

*Water molecules are not included.