6Y03
Structure of Human Aldose Reductase Mutant L300/301A with a Citrate Molecule Bound in the Anion Binding Pocket
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Aldo-keto reductase family 1 member B1 | polymer | 316 | 35814.2 | 1 | UniProt (P15121) Pfam (PF00248) | Homo sapiens (Human) | Aldehyde reductase,Aldose reductase,AR |
| 2 | B (A) | CITRIC ACID | non-polymer | 192.1 | 1 | Chemie (CIT) | |||
| 3 | C (A) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) | |||
| 4 | D (A) | water | water | 18.0 | 257 | Chemie (HOH) |
Sequence modifications
A: 0 - 315 (UniProt: P15121)
| PDB | External Database | Details |
|---|---|---|
| Ile 4 | Leu 5 | conflict |
| Ala 300 | Leu 301 | engineered mutation |
| Ala 301 | Leu 302 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35814.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 935.5 | |
| All* | Total formula weight | 36749.7 |
