6XZQ

Influenza C virus polymerase in complex with human ANP32A - Subclass 1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (I)	RNA (5'-R(*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*GP*CP*CP*CP*UP*G)-3')	polymer	47	14901.7	1		synthetic construct
2	B, E (A, D)	Polymerase acidic protein	polymer	709	82025.5	2	UniProt (Q9IMP5)	Influenza C virus (strain C/Johannesburg/1/1966)	RNA-directed RNA polymerase subunit P2
3	C, F (B, E)	RNA-directed RNA polymerase catalytic subunit	polymer	754	86145.9	2	UniProt (Q9IMP4)	Influenza C virus (strain C/Johannesburg/1/1966)	Polymerase basic protein 1,PB1,RNA-directed RNA polymerase subunit P1
4	D, G (C, F)	Polymerase basic protein 2	polymer	920	104272.4	2	UniProt (Q9IMP3)	Influenza C virus (strain C/Johannesburg/1/1966)	RNA-directed RNA polymerase subunit P3
5	H (G)	Acidic leucine-rich nuclear phosphoprotein 32 family member A	polymer	263	30328.2	1	UniProt (P39687) Pfam (PF14580)	Homo sapiens (Human)	Acidic nuclear phosphoprotein pp32,pp32,Leucine-rich acidic nuclear protein,LANP,Mapmodulin,Potent heat-stable protein phosphatase 2A inhibitor I1PP2A,Putative HLA-DR-associated protein I,PHAPI

Sequence modifications

C, F: 1 - 774 (UniProt: Q9IMP3)

PDB	External Database	Details
Glu 775	-	expression tag
Asn 776	-	expression tag
Leu 777	-	expression tag
Tyr 778	-	expression tag
Phe 779	-	expression tag
Gln 780	-	expression tag
Gly 781	-	expression tag
Glu 782	-	expression tag
Leu 783	-	expression tag
Lys 784	-	expression tag
Thr 785	-	expression tag
Ala 786	-	expression tag
Ala 787	-	expression tag
Leu 788	-	expression tag
Ala 789	-	expression tag
Gln 790	-	expression tag
His 791	-	expression tag
Asp 792	-	expression tag
Glu 793	-	expression tag
Ala 794	-	expression tag
Val 795	-	expression tag
Asp 796	-	expression tag
Asn 797	-	expression tag
Lys 798	-	expression tag
Phe 799	-	expression tag
Asn 800	-	expression tag
Lys 801	-	expression tag
Glu 802	-	expression tag
Gln 803	-	expression tag
Gln 804	-	expression tag
Asn 805	-	expression tag
Ala 806	-	expression tag
Phe 807	-	expression tag
Tyr 808	-	expression tag
Glu 809	-	expression tag
Ile 810	-	expression tag
Leu 811	-	expression tag
His 812	-	expression tag
Leu 813	-	expression tag
Pro 814	-	expression tag
Asn 815	-	expression tag
Leu 816	-	expression tag
Asn 817	-	expression tag
Glu 818	-	expression tag
Glu 819	-	expression tag
Gln 820	-	expression tag
Arg 821	-	expression tag
Asn 822	-	expression tag
Ala 823	-	expression tag
Phe 824	-	expression tag
Ile 825	-	expression tag
Gln 826	-	expression tag
Ser 827	-	expression tag
Leu 828	-	expression tag
Lys 829	-	expression tag
Asp 830	-	expression tag
Asp 831	-	expression tag
Pro 832	-	expression tag
Ser 833	-	expression tag
Gln 834	-	expression tag
Ser 835	-	expression tag
Ala 836	-	expression tag
Asn 837	-	expression tag
Leu 838	-	expression tag
Leu 839	-	expression tag
Ala 840	-	expression tag
Glu 841	-	expression tag
Ala 842	-	expression tag
Lys 843	-	expression tag
Lys 844	-	expression tag
Leu 845	-	expression tag
Asn 846	-	expression tag
Asp 847	-	expression tag
Ala 848	-	expression tag
Gln 849	-	expression tag
Ala 850	-	expression tag
Pro 851	-	expression tag
Lys 852	-	expression tag
Val 853	-	expression tag
Asp 854	-	expression tag
Asn 855	-	expression tag
Lys 856	-	expression tag
Phe 857	-	expression tag
Asn 858	-	expression tag
Lys 859	-	expression tag
Glu 860	-	expression tag
Gln 861	-	expression tag
Gln 862	-	expression tag
Asn 863	-	expression tag
Ala 864	-	expression tag
Phe 865	-	expression tag
Tyr 866	-	expression tag
Glu 867	-	expression tag
Ile 868	-	expression tag
Leu 869	-	expression tag
His 870	-	expression tag
Leu 871	-	expression tag
Pro 872	-	expression tag
Asn 873	-	expression tag
Leu 874	-	expression tag
Asn 875	-	expression tag
Glu 876	-	expression tag
Glu 877	-	expression tag
Gln 878	-	expression tag
Arg 879	-	expression tag
Asn 880	-	expression tag
Ala 881	-	expression tag
Phe 882	-	expression tag
Ile 883	-	expression tag
Gln 884	-	expression tag
Ser 885	-	expression tag
Leu 886	-	expression tag
Lys 887	-	expression tag
Ala 888	-	expression tag
Asp 889	-	expression tag
Pro 890	-	expression tag
Ser 891	-	expression tag
Gln 892	-	expression tag
Ser 893	-	expression tag
Ala 894	-	expression tag
Asn 895	-	expression tag
Leu 896	-	expression tag
Leu 897	-	expression tag
Ala 898	-	expression tag
Glu 899	-	expression tag
Ala 900	-	expression tag
Lys 901	-	expression tag
Lys 902	-	expression tag
Leu 903	-	expression tag
Asn 904	-	expression tag
Gly 905	-	expression tag
Ala 906	-	expression tag
Gln 907	-	expression tag
Ala 908	-	expression tag
Pro 909	-	expression tag
Lys 910	-	expression tag
Val 911	-	expression tag
Asp 912	-	expression tag
Ala 913	-	expression tag
Asn 914	-	expression tag
Ser 915	-	expression tag
Ala 916	-	expression tag
Gly 917	-	expression tag
Lys 918	-	expression tag
Ser 919	-	expression tag
Thr 920	-	expression tag

G: 1 - 249 (UniProt: P39687)

PDB	External Database	Details
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
Leu -7	-	expression tag
Glu -6	-	expression tag
Val -5	-	expression tag
Leu -4	-	expression tag
Phe -3	-	expression tag
Glu -2	-	expression tag
Gly -1	-	expression tag
Pro 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	590117.6
All*	Total formula weight	590117.6

*Water molecules are not included.