6XX4
Crystal structure of the c-Src SH3 domain H122R-Q128E mutant in complex with Ni(II) at pH 7.5 co-crystallized with methyl beta-cyclodextrin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Proto-oncogene tyrosine-protein kinase Src | polymer | 61 | 6925.5 | 1 | UniProt (P00523) Pfam (PF00018) In PDB | Gallus gallus (Chicken) | Proto-oncogene c-Src,pp60c-src,p60-Src |
| 2 | B | Cyclic 2,3-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-2,6-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-3-O-methyl-alpha-D-glucopyranose | branched | 1251.2 | 1 | In PDB BIRD (PRD_900086) GlyTouCan (G04274SM) | methyl-beta-cyclodextrin | ||
| 3 | A | NICKEL (II) ION | non-polymer | 58.7 | 1 | Chemie (NI) | |||
| 4 | water | water | 18.0 | 37 | Chemie (HOH) |
Sequence modifications
A: 85 - 141 (UniProt: P00523)
| PDB | External Database | Details |
|---|---|---|
| Gly 81 | - | expression tag |
| Ser 82 | - | expression tag |
| His 83 | - | expression tag |
| Met 84 | - | expression tag |
| Arg 122 | His 122 | engineered mutation |
| Glu 128 | Gln 128 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 6925.5 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 1251.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 58.7 | |
| All* | Total formula weight | 8235.4 |
