6XTY
CryoEM structure of human CMG bound to AND-1 (CMGA)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | 2 | DNA replication licensing factor MCM2 | polymer | 904 | 102034.1 | 1 | UniProt (P49736) Pfam (PF12619) Pfam (PF14551) Pfam (PF17207) Pfam (PF00493) Pfam (PF17855) In PDB | Homo sapiens (Human) | Minichromosome maintenance protein 2 homolog,Nuclear protein BM28 |
| 2 | 3 | DNA replication licensing factor MCM3 | polymer | 853 | 96043.3 | 1 | UniProt (P25205) Pfam (PF14551) Pfam (PF17207) Pfam (PF00493) Pfam (PF17855) In PDB | Homo sapiens (Human) | DNA polymerase alpha holoenzyme-associated protein P1,P1-MCM3,RLF subunit beta,p102 |
| 3 | 4 | DNA replication licensing factor MCM4 | polymer | 863 | 96684.9 | 1 | UniProt (P33991) Pfam (PF14551) Pfam (PF17207) Pfam (PF00493) Pfam (PF17855) Pfam (PF21128) In PDB | Homo sapiens (Human) | CDC21 homolog,P1-CDC21 |
| 4 | 5 | DNA replication licensing factor MCM5 | polymer | 734 | 82406.6 | 1 | UniProt (P33992) Pfam (PF14551) Pfam (PF17207) Pfam (PF00493) Pfam (PF17855) In PDB | Homo sapiens (Human) | CDC46 homolog,P1-CDC46 |
| 5 | 6 | DNA replication licensing factor MCM6 | polymer | 821 | 93010.3 | 1 | UniProt (Q14566) Pfam (PF14551) Pfam (PF17207) Pfam (PF00493) Pfam (PF17855) Pfam (PF18263) In PDB | Homo sapiens (Human) | p105MCM |
| 6 | 7 | DNA replication licensing factor MCM7 | polymer | 719 | 81411.9 | 1 | UniProt (P33993) Pfam (PF14551) Pfam (PF17207) Pfam (PF00493) Pfam (PF17855) In PDB | Homo sapiens (Human) | CDC47 homolog,P1.1-MCM3 |
| 7 | A | DNA replication complex GINS protein PSF1 | polymer | 196 | 23022.5 | 1 | UniProt (Q14691) Pfam (PF05916) In PDB | Homo sapiens (Human) | GINS complex subunit 1 |
| 8 | B | DNA replication complex GINS protein PSF2 | polymer | 185 | 21453.7 | 1 | UniProt (Q9Y248) Pfam (PF05916) In PDB | Homo sapiens (Human) | GINS complex subunit 2 |
| 9 | C | DNA replication complex GINS protein PSF3 | polymer | 216 | 24562.6 | 1 | UniProt (Q9BRX5) Pfam (PF05916) In PDB | Homo sapiens (Human) | GINS complex subunit 3 |
| 10 | D | DNA replication complex GINS protein SLD5 | polymer | 223 | 26081.9 | 1 | UniProt (Q9BRT9) Pfam (PF05916) Pfam (PF16922) In PDB | Homo sapiens (Human) | GINS complex subunit 4 |
| 11 | E | Cell division control protein 45 homolog | polymer | 566 | 65650.6 | 1 | UniProt (O75419) Pfam (PF02724) In PDB | Homo sapiens (Human) | PORC-PI-1 |
| 12 | F, G, H | WD repeat and HMG-box DNA-binding protein 1 | polymer | 1171 | 130484.8 | 3 | UniProt (O75717) Pfam (PF00400) Pfam (PF12894) Pfam (PF12341) Pfam (PF20946) In PDB | Homo sapiens (Human) | Acidic nucleoplasmic DNA-binding protein 1,And-1 |
| 13 | 2, 4, 5, 6, 7 | ZINC ION | non-polymer | 65.4 | 5 | Chemie (ZN) |
Sequence modifications
E: 1 - 566 (UniProt: O75419)
F, G, H: 1 - 1129 (UniProt: O75717)
| PDB | External Database | Details |
|---|---|---|
| Gln 346 | Glu 346 | variant |
| PDB | External Database | Details |
|---|---|---|
| Met -41 | - | initiating methionine |
| Ser -40 | - | expression tag |
| Ala -39 | - | expression tag |
| Trp -38 | - | expression tag |
| Ser -37 | - | expression tag |
| His -36 | - | expression tag |
| Pro -35 | - | expression tag |
| Gln -34 | - | expression tag |
| Phe -33 | - | expression tag |
| Glu -32 | - | expression tag |
| Lys -31 | - | expression tag |
| Gly -30 | - | expression tag |
| Gly -29 | - | expression tag |
| Gly -28 | - | expression tag |
| Ser -27 | - | expression tag |
| Gly -26 | - | expression tag |
| Gly -25 | - | expression tag |
| Gly -24 | - | expression tag |
| Ser -23 | - | expression tag |
| Gly -22 | - | expression tag |
| Gly -21 | - | expression tag |
| Ser -20 | - | expression tag |
| Ala -19 | - | expression tag |
| Trp -18 | - | expression tag |
| Ser -17 | - | expression tag |
| His -16 | - | expression tag |
| Pro -15 | - | expression tag |
| Gln -14 | - | expression tag |
| Phe -13 | - | expression tag |
| Glu -12 | - | expression tag |
| Lys -11 | - | expression tag |
| Glu -10 | - | expression tag |
| Asn -9 | - | expression tag |
| Leu -8 | - | expression tag |
| Tyr -7 | - | expression tag |
| Phe -6 | - | expression tag |
| Gln -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Ala -1 | - | expression tag |
| Thr 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 14 |
| Total formula weight | 1103816.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 327.0 | |
| All* | Total formula weight | 1104143.6 |
