6XTK
Y114C Transthyretin structure in complex with Tolcalpone
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Transthyretin | polymer | 116 | 12643.2 | 2 | UniProt (P02766) Pfam (PF00576) | Homo sapiens (Human) | ATTR,Prealbumin,TBPA |
| 2 | C, D (A, B) | Tolcapone | non-polymer | 273.2 | 2 | Chemie (TCW) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 101 | Chemie (HOH) |
Sequence modifications
A, B: 10 - 125 (UniProt: P02766)
| PDB | External Database | Details |
|---|---|---|
| Cys 114 | Tyr 134 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 25286.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 546.5 | |
| All* | Total formula weight | 25832.9 |
