6XSK
Cryo-EM Structure of Vaccine-Elicited Rhesus Antibody 789-203-3C12 in Complex with Stabilized SI06 (A/Solomon Islands/3/06) Influenza Hemagglutinin Trimer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, I, K (L, J, K) | 789-203-3C12 Fab Light Chain | polymer | 214 | 23209.7 | 3 | Macaca mulatta | ||
| 2 | B, J, L (H, G, I) | 789-203-3C12 Fab Heavy Chain | polymer | 455 | 49298.6 | 3 | Macaca mulatta | ||
| 3 | C, E, G (A, C, E) | Hemagglutinin HA1 chain | polymer | 343 | 38269.2 | 3 | UniProt (A7Y8I1) | Influenza A virus (A/Solomon Islands/3/2006(H1N1)) | |
| 4 | D, F, H (B, D, F) | Hemagglutinin HA2 chain | polymer | 222 | 25264.1 | 3 | UniProt (A7Y8I1) | Influenza A virus (A/Solomon Islands/3/2006(H1N1)) | |
| 5 | M, Q, T (M, Q, T) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
| 6 | N, O, P, R, S... (N, O, P, R, S...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 6 | In PDB GlyTouCan (G42666HT) | |||
| 7 | AA, BA, CA, DA, EA... (C, D, E, F, A...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 15 | Chemie (NAG) |
Sequence modifications
A, C, E: -6 - 329 (UniProt: A7Y8I1)
B, D, F: 1 - 176 (UniProt: A7Y8I1)
| PDB | External Database | Details |
|---|---|---|
| Cys 30 | Leu 37 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Cys 47 | Gly 390 | conflict |
| Ser 177 | - | expression tag |
| Gly 178 | - | expression tag |
| Arg 179 | - | expression tag |
| Leu 180 | - | expression tag |
| Val 181 | - | expression tag |
| Pro 182 | - | expression tag |
| Arg 183 | - | expression tag |
| Gly 184 | - | expression tag |
| Ser 185 | - | expression tag |
| Pro 186 | - | expression tag |
| Gly 187 | - | expression tag |
| Ser 188 | - | expression tag |
| Gly 189 | - | expression tag |
| Tyr 190 | - | expression tag |
| Ile 191 | - | expression tag |
| Pro 192 | - | expression tag |
| Glu 193 | - | expression tag |
| Ala 194 | - | expression tag |
| Pro 195 | - | expression tag |
| Arg 196 | - | expression tag |
| Asp 197 | - | expression tag |
| Gly 198 | - | expression tag |
| Gln 199 | - | expression tag |
| Ala 200 | - | expression tag |
| Tyr 201 | - | expression tag |
| Val 202 | - | expression tag |
| Arg 203 | - | expression tag |
| Lys 204 | - | expression tag |
| Asp 205 | - | expression tag |
| Gly 206 | - | expression tag |
| Glu 207 | - | expression tag |
| Trp 208 | - | expression tag |
| Val 209 | - | expression tag |
| Leu 210 | - | expression tag |
| Leu 211 | - | expression tag |
| Ser 212 | - | expression tag |
| Thr 213 | - | expression tag |
| Phe 214 | - | expression tag |
| Leu 215 | - | expression tag |
| Gly 216 | - | expression tag |
| His 217 | - | expression tag |
| His 218 | - | expression tag |
| His 219 | - | expression tag |
| His 220 | - | expression tag |
| His 221 | - | expression tag |
| His 222 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 408124.7 | |
| Branched | Number of molecules | 9 |
| Total formula weight | 4306.0 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 3318.1 | |
| All* | Total formula weight | 415748.9 |
