6XRL
Crystal structure of human PI3K-gamma in complex with inhibitor IPI-549
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | polymer | 949 | 108745.9 | 1 | UniProt (P48736) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) In PDB | Homo sapiens (Human) | PtdIns-3-kinase subunit gamma,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma,p110gamma,Phosphoinositide-3-kinase catalytic gamma polypeptide,Serine/threonine protein kinase PIK3CG,p120-PI3K |
| 2 | A | 2-amino-N-[(1S)-1-{8-[(1-methyl-1H-pyrazol-4-yl)ethynyl]-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl}ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | non-polymer | 528.6 | 1 | Chemie (V7Y) | |||
| 3 | A | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A: 144 - 1091 (UniProt: P48736)
| PDB | External Database | Details |
|---|---|---|
| Met 143 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 108745.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 720.7 | |
| All* | Total formula weight | 109466.6 |
