6XLX
Crystal structure of cancer-associated G301D mutant of U2AF65 bound to AdML splice site
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Splicing factor U2AF 65 kDa subunit | polymer | 204 | 22295.4 | 1 | UniProt (P26368) Pfam (PF00076) | Homo sapiens (Human) | U2 auxiliary factor 65 kDa subunit,hU2AF65,U2 snRNP auxiliary factor large subunit |
| 2 | B (B) | DNA/RNA (5'-R(P*UP*UP*(UD)P*UP*U)-D(P*(BRU))-R(P*CP*C)-3') | polymer | 8 | 2449.3 | 1 | synthetic construct | ||
| 3 | C, D (A, B) | water | water | 18.0 | 178 | Chemie (HOH) |
Sequence modifications
A: 141 - 341 (UniProt: P26368)
| PDB | External Database | Details |
|---|---|---|
| Gly 138 | - | expression tag |
| Pro 139 | - | expression tag |
| Leu 140 | - | expression tag |
| Asp 301 | Gly 301 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 24744.7 | |
| All* | Total formula weight | 24744.7 |
