6XL8
Crystal structure of 3-O-Sulfotransferase isoform 3 in complex with 8mer oligosaccharide with no 6S sulfation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 | polymer | 273 | 31216.0 | 2 | UniProt (Q9Y663) Pfam (PF00685) | Homo sapiens (Human) | Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1,h3-OST-3A |
| 2 | C (C) | beta-D-glucopyranuronic acid-(1-4)-2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose | branched | 1430.2 | 1 | In PDB GlyTouCan (G85866ZV) | |||
| 3 | D (D) | beta-D-glucopyranuronic acid-(1-4)-2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid | branched | 1606.3 | 1 | In PDB GlyTouCan (G14932EO) | |||
| 4 | E, J (A, B) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) PubChem (923) | |||
| 5 | F, L (A, B) | ADENOSINE-3'-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (A3P) PubChem (73) PubChem (159296) PubChem (11796727) PubChem (13832521) PubChem (176478997) PubChem (46936223) PubChem (124507383) PubChem (57294977) PubChem (162468645) PubChem (92209390) PubChem (162966793) | |||
| 6 | G, H, I, M, N... (A, B) | IODIDE ION | non-polymer | 126.9 | 9 | Chemie (IOD) PubChem (30165) | |||
| 7 | K (B) | P-NITROPHENOL | non-polymer | 139.1 | 1 | Chemie (NPO) PubChem (980) | |||
| 8 | S, T (A, B) | water | water | 18.0 | 71 | Chemie (HOH) |
Sequence modifications
A, B: 139 - 406 (UniProt: Q9Y663)
| PDB | External Database | Details |
|---|---|---|
| Gly 134 | - | expression tag |
| Ser 135 | - | expression tag |
| Pro 136 | - | expression tag |
| Asn 137 | - | expression tag |
| Ser 138 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 62431.9 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 3036.5 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 2181.6 | |
| All* | Total formula weight | 67650.0 |
