6XKG
Crystal structure of 3-O-Sulfotransferase isoform 3 in complex with 8mer oligosaccharide with 6S sulfation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (B, A) | Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 | polymer | 273 | 31216.0 | 2 | UniProt (Q9Y663) Pfam (PF00685) | Homo sapiens (Human) | Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1,h3-OST-3A |
| 2 | C (D) | 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid | branched | 1670.4 | 1 | In PDB GlyTouCan (G99840HT) | |||
| 3 | D (E) | 2-acetamido-2-deoxy-6-O-sulfo-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid | branched | 2129.7 | 1 | In PDB GlyTouCan (G08563GJ) | |||
| 4 | E, M (B, A) | P-NITROPHENOL | non-polymer | 139.1 | 2 | Chemie (NPO) | |||
| 5 | F, N (B, A) | ADENOSINE-3'-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (A3P) | |||
| 6 | G, O (B, A) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 7 | H, I, J, K, L... (B, A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 7 | Chemie (EDO) | |||
| 8 | R, S (B, A) | water | water | 18.0 | 687 | Chemie (HOH) |
Sequence modifications
B, A: 139 - 406 (UniProt: Q9Y663)
| PDB | External Database | Details |
|---|---|---|
| Gly 134 | - | expression tag |
| Ser 135 | - | expression tag |
| Pro 136 | - | expression tag |
| Asn 137 | - | expression tag |
| Ser 138 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 62431.9 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 3800.1 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 1613.1 | |
| All* | Total formula weight | 67845.1 |
