6XIW
Cryo-EM structure of the sodium leak channel NALCN-FAM155A complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sodium leak channel non-selective protein | polymer | 1794 | 206341.6 | 1 | UniProt (Q8IZF0) Pfam (PF00520) | Homo sapiens (Human) | CanIon,Voltage gated channel-like protein 1 |
| 2 | B (B) | Transmembrane protein FAM155A | polymer | 483 | 54205.0 | 1 | UniProt (B1AL88) | Homo sapiens (Human) | |
| 3 | C, D (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 4 | E, F, G, H, I (A) | (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE | non-polymer | 720.0 | 5 | Chemie (PEV) PubChem (5326793) PubChem (9546967) PubChem (16040250) | |||
| 5 | J, K (A) | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE | non-polymer | 749.0 | 2 | Chemie (PGV) PubChem (21158857) PubChem (73746220) PubChem (5289145) PubChem (162368821) PubChem (163029036) | |||
| 6 | L, M, N (A) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 3 | Chemie (Y01) PubChem (16219150) PubChem (22210610) PubChem (65082) PubChem (45489984) PubChem (363416) PubChem (60078761) PubChem (500055) PubChem (73440805) PubChem (57163942) PubChem (89891013) PubChem (99567468) PubChem (124427194) PubChem (124897021) PubChem (124897020) PubChem (10005657) PubChem (130340716) PubChem (99567469) PubChem (11969853) PubChem (137392566) PubChem (137496323) PubChem (124301053) PubChem (124302591) PubChem (124303794) PubChem (124421343) PubChem (124427195) PubChem (13301926) PubChem (13301927) PubChem (124914595) PubChem (124914596) PubChem (155804219) PubChem (169132514) PubChem (131705526) PubChem (137332121) PubChem (137496357) PubChem (146157332) PubChem (154929912) PubChem (155199678) PubChem (156327905) PubChem (156426247) PubChem (156516588) PubChem (166979870) PubChem (167024614) PubChem (169132513) PubChem (170117245) PubChem (172400028) | |||
| 7 | O, P (A, B) | water | water | 18.0 | 5 | Chemie (HOH) |
Sequence modifications
A: 1 - 1738 (UniProt: Q8IZF0)
B: 1 - 458 (UniProt: B1AL88)
| PDB | External Database | Details |
|---|---|---|
| Gly 1739 | - | expression tag |
| Gly 1740 | - | expression tag |
| Gly 1741 | - | expression tag |
| Ser 1742 | - | expression tag |
| Gly 1743 | - | expression tag |
| Gly 1744 | - | expression tag |
| Trp 1745 | - | expression tag |
| Ser 1746 | - | expression tag |
| His 1747 | - | expression tag |
| Pro 1748 | - | expression tag |
| Gln 1749 | - | expression tag |
| Phe 1750 | - | expression tag |
| Glu 1751 | - | expression tag |
| Lys 1752 | - | expression tag |
| Gly 1753 | - | expression tag |
| Gly 1754 | - | expression tag |
| Gly 1755 | - | expression tag |
| Ser 1756 | - | expression tag |
| Gly 1757 | - | expression tag |
| Gly 1758 | - | expression tag |
| Gly 1759 | - | expression tag |
| Ser 1760 | - | expression tag |
| Gly 1761 | - | expression tag |
| Gly 1762 | - | expression tag |
| Ser 1763 | - | expression tag |
| Ala 1764 | - | expression tag |
| Trp 1765 | - | expression tag |
| Ser 1766 | - | expression tag |
| His 1767 | - | expression tag |
| Pro 1768 | - | expression tag |
| Gln 1769 | - | expression tag |
| Phe 1770 | - | expression tag |
| Glu 1771 | - | expression tag |
| Lys 1772 | - | expression tag |
| Gly 1773 | - | expression tag |
| Ser 1774 | - | expression tag |
| Gly 1775 | - | expression tag |
| Asp 1776 | - | expression tag |
| Tyr 1777 | - | expression tag |
| Lys 1778 | - | expression tag |
| Asp 1779 | - | expression tag |
| Asp 1780 | - | expression tag |
| Asp 1781 | - | expression tag |
| Asp 1782 | - | expression tag |
| Lys 1783 | - | expression tag |
| Gly 1784 | - | expression tag |
| Asn 1785 | - | expression tag |
| Ser 1786 | - | expression tag |
| Asp 1787 | - | expression tag |
| Tyr 1788 | - | expression tag |
| Lys 1789 | - | expression tag |
| Asp 1790 | - | expression tag |
| Asp 1791 | - | expression tag |
| Asp 1792 | - | expression tag |
| Asp 1793 | - | expression tag |
| Lys 1794 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 459 | - | expression tag |
| Gly 460 | - | expression tag |
| Ser 461 | - | expression tag |
| Gly 462 | - | expression tag |
| Gly 463 | - | expression tag |
| Ser 464 | - | expression tag |
| Asp 465 | - | expression tag |
| Tyr 466 | - | expression tag |
| Lys 467 | - | expression tag |
| Asp 468 | - | expression tag |
| Asp 469 | - | expression tag |
| Asp 470 | - | expression tag |
| Asp 471 | - | expression tag |
| Lys 472 | - | expression tag |
| Gly 473 | - | expression tag |
| Asn 474 | - | expression tag |
| Ser 475 | - | expression tag |
| Asp 476 | - | expression tag |
| Tyr 477 | - | expression tag |
| Lys 478 | - | expression tag |
| Asp 479 | - | expression tag |
| Asp 480 | - | expression tag |
| Asp 481 | - | expression tag |
| Asp 482 | - | expression tag |
| Lys 483 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 260546.6 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 7000.7 | |
| All* | Total formula weight | 267547.3 |
