6XDH

Crystal Structure of NendoU (Uridylate-specific endoribonuclease, nsp15) from Betacoronavirus SARS-CoV-2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Uridylate-specific endoribonuclease	polymer	368	41396.9	2	UniProt (P0DTD1) Pfam (PF19219) Pfam (PF19216) Pfam (PF19215)	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)	NendoU, nsp15
2	C, H, K (A, B)	ACETATE ION	non-polymer		59.0	3	Chemie (ACT)
3	D, J (A, B)	CITRIC ACID	non-polymer		192.1	2	Chemie (CIT)
4	E, F, G, I, M (A, B)	FORMIC ACID	non-polymer		46.0	5	Chemie (FMT)
5	L (B)	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
6	N, O (A, B)	water	water		18.0	421	Chemie (HOH)

Sequence modifications

A, B: 2 - 347 (UniProt: P0DTD1)

PDB	External Database	Details
Met -20	-	expression tag
Gly -19	-	expression tag
Ser -18	-	expression tag
Ser -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Ser -10	-	expression tag
Ser -9	-	expression tag
Gly -8	-	expression tag
Glu -7	-	expression tag
Asn -6	-	expression tag
Leu -5	-	expression tag
Tyr -4	-	expression tag
Phe -3	-	expression tag
Gln -2	-	expression tag
Gly -1	-	expression tag
His 0	-	expression tag
Met 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	82793.9
Non-Polymers*	Number of molecules	11
	Total formula weight	853.6
All*	Total formula weight	83647.4

*Water molecules are not included.