6XBJ
Structure of human SMO-D384R complex with Gi
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | R | Smoothened homolog | polymer | 652 | 71828.5 | 1 | UniProt (Q99835) Pfam (PF01392) Pfam (PF01534) In PDB | Homo sapiens (Human) | SMO,Protein Gx |
2 | A | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40415.0 | 1 | UniProt (P63096) Pfam (PF00503) In PDB | Homo sapiens (Human) | Adenylate cyclase-inhibiting G alpha protein |
3 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 344 | 37671.1 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (Human) | Transducin beta chain 1 |
4 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (Human) | G gamma-I |
5 | S | scFv16 | polymer | 259 | 27784.9 | 1 | Mus musculus | ||
6 | R | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) |
Sequence modifications
R: 1 - 644 (UniProt: Q99835)
B: 2 - 340 (UniProt: P62873)
PDB | External Database | Details |
---|---|---|
Arg 384 | Asp 384 | engineered mutation |
Asp 645 | - | expression tag |
Tyr 646 | - | expression tag |
Lys 647 | - | expression tag |
Asp 648 | - | expression tag |
Asp 649 | - | expression tag |
Asp 650 | - | expression tag |
Asp 651 | - | expression tag |
Lys 652 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Pro -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 185560.7 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 386.7 | |
All* | Total formula weight | 185947.4 |