6X6Y

Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with inhibitor SGT1264

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	AAA	N-acetyltransferase Eis	polymer	422	45999.1	1	UniProt (P9WFK7) Pfam (PF13527) Pfam (PF17668) Pfam (PF13530) In PDB	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	Aminoglycoside N-acetyltransferase,Enhanced intracellular survival protein,Protein-lysine N-acetyltransferase
2	AAA	N-[4-(4-fluorophenyl)-4-oxobutyl]guanidine	non-polymer		223.2	1	Chemie (USY)
3	AAA	GLYCEROL	non-polymer		92.1	6	Chemie (GOL)
4	AAA	DIMETHYL SULFOXIDE	non-polymer		78.1	2	Chemie (DMS)
5	AAA	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	1	Chemie (PEG)
6	AAA	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
7		water	water		18.0	230	Chemie (HOH)

Sequence modifications

AAA: 1 - 402 (UniProt: P9WFK7)

PDB	External Database	Details
Met -19	-	expression tag
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag
Ala 204	Cys 204	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	45999.1
Non-Polymers*	Number of molecules	11
	Total formula weight	1073.6
All*	Total formula weight	47072.8

*Water molecules are not included.