6X6C
Cryo-EM structure of NLRP1-DPP9-VbP complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B (A, D) | Dipeptidyl peptidase 9 | polymer | 891 | 101762.0 | 2 | UniProt (Q86TI2) Pfam (PF19520) Pfam (PF00930) Pfam (PF00326) | Homo sapiens (Human) | DP9,Dipeptidyl peptidase IV-related protein 2,DPRP-2,Dipeptidyl peptidase IX,DPP IX,Dipeptidyl peptidase-like protein 9,DPLP9 |
2 | C, D (E, F) | NACHT, LRR and PYD domains-containing protein 1 | polymer | 1473 | 166069.5 | 2 | UniProt (Q9C000) Pfam (PF13516) Pfam (PF13553) Pfam (PF00619) Pfam (PF02758) Pfam (PF05729) Pfam (PF17779) Pfam (PF17776) Pfam (PF00560) | Homo sapiens (Human) | Caspase recruitment domain-containing protein 7,Death effector filament-forming ced-4-like apoptosis protein,Nucleotide-binding domain and caspase recruitment domain |
3 | E, F (A, D) | [(2~{R})-1-[(2~{R})-2-azanyl-3-methyl-butanoyl]pyrrolidin-2-yl]boronic acid | non-polymer | 214.1 | 2 | Chemie (GK2) |
Sequence modifications
A, D: 1 - 863 (UniProt: Q86TI2)
PDB | External Database | Details |
---|---|---|
Met -27 | - | expression tag |
Ser -26 | - | expression tag |
Tyr -25 | - | expression tag |
Tyr -24 | - | expression tag |
His -23 | - | expression tag |
His -22 | - | expression tag |
His -21 | - | expression tag |
His -20 | - | expression tag |
His -19 | - | expression tag |
His -18 | - | expression tag |
Asp -17 | - | expression tag |
Tyr -16 | - | expression tag |
Asp -15 | - | expression tag |
Ile -14 | - | expression tag |
Pro -13 | - | expression tag |
Thr -12 | - | expression tag |
Thr -11 | - | expression tag |
Glu -10 | - | expression tag |
Asn -9 | - | expression tag |
Leu -8 | - | expression tag |
Tyr -7 | - | expression tag |
Phe -6 | - | expression tag |
Gln -5 | - | expression tag |
Gly -4 | - | expression tag |
Ala -3 | - | expression tag |
Met -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 535662.9 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 428.1 | |
All* | Total formula weight | 536091.1 |