6X5L
Discovery of Hydroxy Pyrimidine Factor IXa Inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Coagulation factor IX | polymer | 234 | 26089.7 | 1 | UniProt (P00740) Pfam (PF00089) | Homo sapiens (Human) | Christmas factor,Plasma thromboplastin component,PTC |
| 2 | B (B) | Coagulation factor IX | polymer | 62 | 6841.8 | 1 | UniProt (P00740) Pfam (PF14670) | Homo sapiens (Human) | Christmas factor,Plasma thromboplastin component,PTC |
| 3 | C (A) | 4-{[5-hydroxy-6-(4-methylphenyl)pyrimidin-4-yl]amino}benzene-1-carboximidamide | non-polymer | 319.4 | 1 | Chemie (UQG) | |||
| 4 | D (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 5 | E, F, G, H (A) | CITRIC ACID | non-polymer | 192.1 | 4 | Chemie (CIT) | |||
| 6 | I, J (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 7 | K, L (A, B) | water | water | 18.0 | 131 | Chemie (HOH) |
Sequence modifications
B: 85 - 145 (UniProt: P00740)
| PDB | External Database | Details |
|---|---|---|
| Met 84 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 32931.5 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1295.0 | |
| All* | Total formula weight | 34226.6 |
