6X5G
Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and LRRC7 inhibitory domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Calcium/calmodulin-dependent protein kinase type II subunit alpha | polymer | 268 | 30548.1 | 1 | UniProt (Q9UQM7) Pfam (PF00069) In PDB | Homo sapiens (human) | CaMK-II subunit alpha |
| 2 | B | Leucine-rich repeat-containing protein 7 | polymer | 22 | 2500.8 | 1 | UniProt (Q96NW7) In PDB | Homo sapiens | Densin-180,Densin,Protein LAP1 |
| 3 | A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 4 | A | BICINE | non-polymer | 163.2 | 1 | Chemie (BCN) | |||
| 5 | water | water | 18.0 | 107 | Chemie (HOH) |
Sequence modifications
A: 7 - 274 (UniProt: Q9UQM7)
| PDB | External Database | Details |
|---|---|---|
| Asn 135 | Asp 135 | engineered mutation |
| Lys 223 | Gln 223 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 33048.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 347.4 | |
| All* | Total formula weight | 33396.3 |
