6X5A
The mouse cGAS catalytic domain binding to human nucleosome that purified from HEK293T cells
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, E | Histone H3.2 | polymer | 135 | 15257.8 | 2 | UniProt (Q71DI3) Pfam (PF00125) In PDB | Homo sapiens (Human) | H3-clustered histone 13,H3-clustered histone 14,H3-clustered histone 15,Histone H3/m,Histone H3/o |
2 | B, F | Histone H4 | polymer | 102 | 11263.2 | 2 | UniProt (P62805) Pfam (PF15511) In PDB | Homo sapiens (Human) | |
3 | C, G | Histone H2A type 1 | polymer | 129 | 13990.3 | 2 | UniProt (P0C0S8) Pfam (PF00125) Pfam (PF16211) In PDB | Homo sapiens (Human) | H2A.1,Histone H2A/ptl |
4 | D, H | Histone H2B type 1-C/E/F/G/I | polymer | 124 | 13708.9 | 2 | UniProt (P62807) Pfam (PF00125) In PDB | Homo sapiens (Human) | Histone H2B.1 A,Histone H2B.a,H2B/a,Histone H2B.g,H2B/g,Histone H2B.h,H2B/h,Histone H2B.k,H2B/k,Histone H2B.l,H2B/l |
5 | I | DNA (natural) | polymer | 147 | 45145.8 | 1 | Homo sapiens (Human) | ||
6 | J | DNA (natural) | polymer | 147 | 45604.0 | 1 | Homo sapiens (Human) | ||
7 | K | Cyclic GMP-AMP synthase | polymer | 372 | 43647.4 | 1 | UniProt (Q8C6L5) Pfam (PF03281) Pfam (PF20266) In PDB | Mus musculus (Mouse) | m-cGAS,2'3'-cGAMP synthase,Mab-21 domain-containing protein 1 |
8 | K | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
A, E: 1 - 135 (UniProt: Q71DI3)
K: 142 - 507 (UniProt: Q8C6L5)
PDB | External Database | Details |
---|---|---|
Ala 110 | Cys 111 | conflict |
PDB | External Database | Details |
---|---|---|
Gly 136 | - | expression tag |
Ser 137 | - | expression tag |
Glu 138 | - | expression tag |
Phe 139 | - | expression tag |
Glu 140 | - | expression tag |
Leu 141 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 11 |
Total formula weight | 242837.8 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 65.4 | |
All* | Total formula weight | 242903.2 |