6X37
Crystal structure of PT3245 bound to HIF2a-B*:ARNT-B* complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Endothelial PAS domain-containing protein 1 | polymer | 115 | 13295.0 | 1 | UniProt (Q99814) Pfam (PF14598) In PDB | Homo sapiens (Human) | EPAS-1,Basic-helix-loop-helix-PAS protein MOP2,Class E basic helix-loop-helix protein 73,bHLHe73,HIF-1-alpha-like factor,HLF,Hypoxia-inducible factor 2-alpha,HIF2-alpha,Member of PAS protein 2,PAS domain-containing protein 2 |
2 | B | Aryl hydrocarbon receptor nuclear translocator | polymer | 118 | 13898.8 | 1 | UniProt (P27540) Pfam (PF14598) In PDB | Homo sapiens (Human) | ARNT protein,Class E basic helix-loop-helix protein 2,bHLHe2,Dioxin receptor,nuclear translocator,Hypoxia-inducible factor 1-beta,HIF1-beta |
3 | A | 3-fluoro-5-{[(7R)-7-hydroxy-1-(trifluoromethyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-4-yl]oxy}benzonitrile | non-polymer | 338.3 | 1 | Chemie (ULS) | |||
4 | water | water | 18.0 | 25 | Chemie (HOH) |
Sequence modifications
A: 239 - 348 (UniProt: Q99814)
B: 356 - 467 (UniProt: P27540)
PDB | External Database | Details |
---|---|---|
Gly -2 | - | expression tag |
Glu -1 | - | expression tag |
Phe 0 | - | expression tag |
Lys 1 | - | expression tag |
Gly 2 | - | expression tag |
Glu 247 | Arg 247 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 350 | - | expression tag |
Glu 351 | - | expression tag |
Phe 352 | - | expression tag |
Lys 353 | - | expression tag |
Gly 354 | - | expression tag |
Leu 355 | - | expression tag |
Arg 362 | Glu 362 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 27193.8 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 338.3 | |
All* | Total formula weight | 27532.1 |