6X1M

Lon protease proteolytic domain complexed with covalent boronic acid inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	Lon protease homolog, mitochondrial	polymer	218	23788.2	3	UniProt (P36776) Pfam (PF05362)	Homo sapiens (Human)	LONHs,Lon protease-like protein,LONP,Mitochondrial ATP-dependent protease Lon,Serine protease 15
2	D, E (A, B)	[(1R)-4-phenyl-1-{[N-(pyrazine-2-carbonyl)-D-norvalyl]amino}butyl]boronic acid	non-polymer		398.3	2	Chemie (UKS)

Sequence modifications

A, B, C: 754 - 959 (UniProt: P36776)

PDB	External Database	Details
Met 742	-	initiating methionine
Gly 743	-	expression tag
Ser 744	-	expression tag
Asp 745	-	expression tag
Lys 746	-	expression tag
Ile 747	-	expression tag
His 748	-	expression tag
His 749	-	expression tag
His 750	-	expression tag
His 751	-	expression tag
His 752	-	expression tag
His 753	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	71364.7
Non-Polymers*	Number of molecules	2
	Total formula weight	796.5
All*	Total formula weight	72161.2

*Water molecules are not included.