6WZG
Human secretin receptor Gs complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (P) | Secretin | polymer | 27 | 3045.4 | 1 | UniProt (P09683) Pfam (PF00123) | Homo sapiens | |
| 2 | B (R) | Secretin receptor | polymer | 453 | 51928.9 | 1 | UniProt (P47872) Pfam (PF02793) Pfam (PF00002) | Homo sapiens (Human) | SCT-R |
| 3 | C (A) | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 394 | 45699.4 | 1 | UniProt (P63092) Pfam (PF00503) | Homo sapiens (Human) | Adenylate cyclase-stimulating G alpha protein |
| 4 | D (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 340 | 37416.9 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (Human) | Transducin beta chain 1 |
| 5 | E (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (Human) | G gamma-I |
| 6 | F (N) | Nanobody35 | polymer | 138 | 15140.7 | 1 | Lama glama (llama) |
Sequence modifications
R: 22 - 440 (UniProt: P47872)
A: 1 - 394 (UniProt: P63092)
| PDB | External Database | Details |
|---|---|---|
| Asp 7 | - | expression tag |
| Tyr 8 | - | expression tag |
| Lys 9 | - | expression tag |
| Asp 10 | - | expression tag |
| Asp 11 | - | expression tag |
| Asp 12 | - | expression tag |
| Asp 13 | - | expression tag |
| Leu 14 | - | expression tag |
| Glu 15 | - | expression tag |
| Val 16 | - | expression tag |
| Leu 17 | - | expression tag |
| Phe 18 | - | expression tag |
| Gln 19 | - | expression tag |
| Gly 20 | - | expression tag |
| Pro 21 | - | expression tag |
| Pro 441 | - | expression tag |
| Ala 442 | - | expression tag |
| Gly 443 | - | expression tag |
| Leu 444 | - | expression tag |
| Glu 445 | - | expression tag |
| Val 446 | - | expression tag |
| Leu 447 | - | expression tag |
| Phe 448 | - | expression tag |
| Gln 449 | - | expression tag |
| Gly 450 | - | expression tag |
| Pro 451 | - | expression tag |
| His 452 | - | expression tag |
| His 453 | - | expression tag |
| His 454 | - | expression tag |
| His 455 | - | expression tag |
| His 456 | - | expression tag |
| His 457 | - | expression tag |
| His 458 | - | expression tag |
| His 459 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asn 54 | Ser 54 | conflict |
| Ala 226 | Gly 226 | conflict |
| Ala 268 | Glu 268 | conflict |
| Lys 271 | Asn 271 | conflict |
| Asp 274 | Lys 274 | conflict |
| Lys 280 | Arg 280 | conflict |
| Asp 284 | Thr 284 | conflict |
| Thr 285 | Ile 285 | conflict |
| Ser 366 | Ala 366 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 161092.5 | |
| All* | Total formula weight | 161092.5 |
