6WY1

Crystal structure of an engineered thermostable dengue virus 2 envelope protein dimer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Dengue 2 soluble recombinant envelope	polymer	408	45694.3	1	UniProt (D0EPS0) Pfam (PF00869) Pfam (PF02832) UniProt (by SIFTS) (P29990) In PDB	Dengue virus 2
2	A	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)

Sequence modifications

A: 1 - 397 (UniProt: D0EPS0)

PDB	External Database	Details
Asp 106	Gly 386	engineered mutation
Trp 259	Ala 539	engineered mutation
Arg 262	Thr 542	engineered mutation
Trp 279	Phe 559	engineered mutation
Pro 280	Thr 560	engineered mutation
Gly 398	-	expression tag
Gly 399	-	expression tag
Ser 400	-	expression tag
His 401	-	expression tag
His 402	-	expression tag
His 403	-	expression tag
His 404	-	expression tag
His 405	-	expression tag
His 406	-	expression tag
His 407	-	expression tag
His 408	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	45694.3
Non-Polymers*	Number of molecules	1
	Total formula weight	221.2
All*	Total formula weight	45915.5

*Water molecules are not included.