6WXL
Cryo-EM structure of the VRC315 clinical trial, vaccine-elicited, human antibody 1D12 in complex with an H7 SH13 HA trimer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, K, L (A, C, G) | Hemagglutinin HA1 chain | polymer | 321 | 35039.5 | 3 | UniProt (A0A067Y6L0) Pfam (PF00509) | Influenza A virus (A/Shanghai/JS01/2013(H7N9)) | |
| 2 | B, E, H (B, D, I) | Hemagglutinin HA2 chain | polymer | 221 | 25234.4 | 3 | UniProt (A0A067Y6L0) Pfam (PF00509) | Influenza A virus (A/Shanghai/JS01/2013(H7N9)) | |
| 3 | C, F, I (L, E, J) | 1D12 Light chain | polymer | 221 | 23971.8 | 3 | Homo sapiens (Human) | ||
| 4 | D, G, J (H, F, K) | 1D21 Heavy chain | polymer | 232 | 25042.2 | 3 | Homo sapiens (Human) | ||
| 5 | M, N, O, P, Q... (A, B, D, I, C...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 9 | Chemie (NAG) |
Sequence modifications
A, C, G: 11 - 330 (UniProt: A0A067Y6L0)
| PDB | External Database | Details |
|---|---|---|
| Ser 138 | Ala 146 | conflict |
| Val 214 | Ala 223 | conflict |
| Tyr 283 | His 292 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 327863.4 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1990.9 | |
| All* | Total formula weight | 329854.3 |
