6WUS

Crystal structure of PRL-1 phosphatase C104D mutant in complex with the Bateman domain of CNNM2 magnesium transporter

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Metal transporter CNNM2	polymer	153	17408.8	1	UniProt (Q3TWN3) Pfam (PF00571)	Mus musculus (Mouse)	Ancient conserved domain-containing protein 2,mACDP2,Cyclin-M2
2	B (B)	Protein tyrosine phosphatase type IVA 1	polymer	164	18812.8	1	UniProt (Q63739) Pfam (PF22785)	Mus musculus (Mouse)	Protein-tyrosine phosphatase 4a1,Protein-tyrosine phosphatase of regenerating liver 1,PRL-1
3	C, D (A, B)	water	water		18.0	9	Chemie (HOH)

Sequence modifications

A: 430 - 580 (UniProt: Q3TWN3)

PDB	External Database	Details
Gly 428	-	expression tag
Ser 429	-	expression tag

B: 7 - 160 (UniProt: Q63739)

PDB	External Database	Details
Met -3	-	initiating methionine
Gly -2	-	expression tag
Ser -1	-	expression tag
Ser 0	-	expression tag
His 1	-	expression tag
His 2	-	expression tag
His 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
Asp 104	Cys 104	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	36221.6
All*	Total formula weight	36221.6

*Water molecules are not included.