6WTP
Human JAK2 JH1 domain in complex with PROTAC-intermediate linker handle 3
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Tyrosine-protein kinase JAK2 | polymer | 309 | 36412.3 | 1 | UniProt (O60674) Pfam (PF07714) In PDB | Homo sapiens (Human) | Janus kinase 2,JAK-2 |
2 | A | tert-butyl 4-[(4-{1-[3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl]-1H-pyrazol-4-yl}-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]benzoate | non-polymer | 562.6 | 1 | Chemie (U8P) | |||
3 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
4 | water | water | 18.0 | 21 | Chemie (HOH) |
Sequence modifications
A: 835 - 1132 (UniProt: O60674)
PDB | External Database | Details |
---|---|---|
Met 834 | - | initiating methionine |
Gly 1133 | - | expression tag |
Ser 1134 | - | expression tag |
Gly 1135 | - | expression tag |
Ser 1136 | - | expression tag |
Glu 1137 | - | expression tag |
Asn 1138 | - | expression tag |
Leu 1139 | - | expression tag |
Tyr 1140 | - | expression tag |
Phe 1141 | - | expression tag |
Gln 1142 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 36412.3 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 654.7 | |
All* | Total formula weight | 37067.0 |