6WRS
Structure of the 50S subunit of the ribosome from Methicillin Resistant Staphylococcus aureus in complex with the antibiotic, tedizolid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 50S ribosomal protein L19 | polymer | 116 | 13392.8 | 1 | UniProt (A0A077UVB6) Pfam (PF01245) UniProt (by SIFTS) (Q2FZ42) | Staphylococcus aureus | |
| 2 | B (B) | 50S ribosomal protein L2 | polymer | 277 | 30217.2 | 1 | UniProt (A0A077W1J0) Pfam (PF00181) Pfam (PF03947) UniProt (by SIFTS) (P60430) | Staphylococcus aureus | |
| 3 | C (C) | 50S ribosomal protein L20 | polymer | 118 | 13720.3 | 1 | UniProt (A0A077VMP6) Pfam (PF00453) UniProt (by SIFTS) (Q2FXQ1) | Staphylococcus aureus | |
| 4 | D (D) | 50S ribosomal protein L21 | polymer | 105 | 11700.5 | 1 | UniProt (A0A0E0VQU6) Pfam (PF00829) UniProt (by SIFTS) (Q2FXS8) | Staphylococcus aureus | |
| 5 | E (E) | uL22 | polymer | 117 | 12871.9 | 1 | UniProt (A7X5F6) Pfam (PF00237) UniProt (by SIFTS) (Q2FW11) | Staphylococcus aureus | |
| 6 | F (F) | 50S ribosomal protein L23 | polymer | 91 | 10627.3 | 1 | UniProt (W8TUB4) Pfam (PF00276) UniProt (by SIFTS) (Q2FW08) | Staphylococcus aureus | |
| 7 | G (G) | 50S ribosomal protein L24 | polymer | 105 | 11591.5 | 1 | UniProt (W8TRD5) Pfam (PF00467) Pfam (PF17136) UniProt (by SIFTS) (Q2FW17) | Staphylococcus aureus | |
| 8 | H (H) | uL25 | polymer | 107 | 12063.1 | 1 | UniProt (A0A2X2JWH5) Pfam (PF01386) UniProt (by SIFTS) (Q2G0S0) | Staphylococcus aureus | |
| 9 | I (J) | 50S ribosomal protein L28 | polymer | 62 | 6967.2 | 1 | UniProt (A0A077URJ8) Pfam (PF00830) UniProt (by SIFTS) (Q2FZ60) | Staphylococcus aureus | |
| 10 | J (K) | 50S ribosomal protein L29 | polymer | 72 | 8491.8 | 1 | UniProt (A0A2S6DIY7) Pfam (PF00831) UniProt (by SIFTS) (Q2FW14) | Staphylococcus aureus | |
| 11 | K (L) | 50S ribosomal protein L3 | polymer | 217 | 23459.9 | 1 | UniProt (W8U3W0) Pfam (PF00297) UniProt (by SIFTS) (Q2FW06) | Staphylococcus aureus | |
| 12 | L (M) | 50S ribosomal protein L30 | polymer | 58 | 6434.5 | 1 | UniProt (W8UVN7) Pfam (PF00327) UniProt (by SIFTS) (P0A0G2) | Staphylococcus aureus | |
| 13 | M (N) | 50S ribosomal protein L32 | polymer | 57 | 6472.6 | 1 | UniProt (A0A077UWR7) Pfam (PF01783) UniProt (by SIFTS) (Q2FZF1) | Staphylococcus aureus | |
| 14 | N (O) | 50S ribosomal protein L33 | polymer | 49 | 5885.8 | 1 | UniProt (A0A077UXT4) Pfam (PF00471) UniProt (by SIFTS) (Q2FY22) | Staphylococcus aureus | |
| 15 | O (P) | 50S ribosomal protein L34 | polymer | 50 | 6064.4 | 1 | UniProt (T1YD75) Pfam (PF00468) UniProt (by SIFTS) (Q2FUQ0) | Staphylococcus aureus | |
| 16 | P (Q) | 50S ribosomal protein L35 | polymer | 65 | 7593.2 | 1 | UniProt (A0A077UL47) Pfam (PF01632) UniProt (by SIFTS) (Q2FXQ0) | Staphylococcus aureus | |
| 17 | Q (R) | 50S ribosomal protein L36 | polymer | 37 | 4318.4 | 1 | UniProt (A0A077UGV8) Pfam (PF00444) UniProt (by SIFTS) (Q2FW29) | Staphylococcus aureus | |
| 18 | R (S) | 50S ribosomal protein L4 | polymer | 207 | 22523.8 | 1 | UniProt (A0A166DK89) Pfam (PF00573) UniProt (by SIFTS) (Q2FW07) | Staphylococcus aureus | |
| 19 | S (V) | 50S ribosomal protein L13 | polymer | 145 | 16359.4 | 1 | UniProt (W8TUE6) Pfam (PF00572) UniProt (by SIFTS) (Q2FW38) | Staphylococcus aureus | |
| 20 | T (W) | 50S ribosomal protein L14 | polymer | 122 | 13157.3 | 1 | UniProt (A0A077UUA0) Pfam (PF00238) UniProt (by SIFTS) (Q2FW16) | Staphylococcus aureus | |
| 21 | U (X) | 50S ribosomal protein L15 | polymer | 146 | 15628.9 | 1 | UniProt (A0A077UGA7) Pfam (PF00828) UniProt (by SIFTS) (P0A0F8) | Staphylococcus aureus | |
| 22 | V (Y) | 50S ribosomal protein L16 | polymer | 144 | 16274.0 | 1 | UniProt (A0A077V4G0) Pfam (PF00252) UniProt (by SIFTS) (Q2FW13) | Staphylococcus aureus | |
| 23 | W (Z) | 50S ribosomal protein L17 | polymer | 122 | 13771.8 | 1 | UniProt (A0A077UG91) Pfam (PF01196) UniProt (by SIFTS) (Q2FW33) | Staphylococcus aureus | |
| 24 | X (a) | 50S ribosomal protein L18 | polymer | 119 | 13124.1 | 1 | UniProt (W8TRE0) Pfam (PF00861) UniProt (by SIFTS) (Q2FW22) | Staphylococcus aureus | |
| 25 | Y (1) | 23S rRNA | polymer | 2923 | 946680.6 | 1 | GenBank (1760383645) | Staphylococcus aureus | |
| 26 | Z (2) | 5S rRNA | polymer | 115 | 36958.0 | 1 | GenBank (1750990749) | Staphylococcus aureus | |
| 27 | AA (I) | 50S ribosomal protein L27 | polymer | 85 | 9198.4 | 1 | UniProt (A0A077ULC5) Pfam (PF01016) UniProt (by SIFTS) (Q2FXT0) | Staphylococcus aureus | |
| 28 | BA (1) | Tedizolid | non-polymer | 370.3 | 1 | Chemie (U7V) |
Sequence modifications
E: 1 - 117 (UniProt: A7X5F6)
F: 1 - 91 (UniProt: W8TUB4)
G: 1 - 105 (UniProt: W8TRD5)
J: 1 - 61 (UniProt: A0A077URJ8)
N: 1 - 57 (UniProt: A0A077UWR7)
1: 1 - 2923 (GenBank: 1760383645)
2: 1 - 115 (GenBank: 1750990749)
| PDB | External Database | Details |
|---|---|---|
| Ala 110 | Gly 110 | variant |
| PDB | External Database | Details |
|---|---|---|
| Asp 87 | Ile 87 | variant |
| PDB | External Database | Details |
|---|---|---|
| Ser 54 | Gly 54 | variant |
| PDB | External Database | Details |
|---|---|---|
| Ala 62 | - | insertion |
| PDB | External Database | Details |
|---|---|---|
| Ala 54 | Val 54 | variant |
| PDB | External Database | Details |
|---|---|---|
| A 1866 | G 560294 | conflict |
| PDB | External Database | Details |
|---|---|---|
| C 80 | G 187450 | variant |
| C 109 | G 187479 | variant |
| A 111 | C 187481 | variant |
| G 112 | A 187482 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 27 |
| Total formula weight | 1295548.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 370.3 | |
| All* | Total formula weight | 1295919.0 |
