6WP3
Pyruvate Kinase M2 Mutant-K433Q
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Pyruvate kinase PKM | polymer | 550 | 60049.0 | 2 | UniProt (P14618) Pfam (PF00224) Pfam (PF02887) In PDB | Homo sapiens (Human) | Cytosolic thyroid hormone-binding protein,CTHBP,Opa-interacting protein 3,OIP-3,Pyruvate kinase 2/3,Pyruvate kinase muscle isozyme,Thyroid hormone-binding protein 1,THBP1,Tumor M2-PK,p58 |
2 | A, B | GLYCEROL | non-polymer | 92.1 | 7 | Chemie (GOL) | |||
3 | A, B | OXALATE ION | non-polymer | 88.0 | 2 | Chemie (OXL) | |||
4 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
5 | A, B | NITRATE ION | non-polymer | 62.0 | 2 | Chemie (NO3) | |||
6 | B | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
7 | B | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
8 | water | water | 18.0 | 385 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 531 (UniProt: P14618)
PDB | External Database | Details |
---|---|---|
Met -18 | - | initiating methionine |
Gly -17 | - | expression tag |
Ser -16 | - | expression tag |
Ser -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
His -9 | - | expression tag |
Ser -8 | - | expression tag |
Ser -7 | - | expression tag |
Gly -6 | - | expression tag |
Leu -5 | - | expression tag |
Val -4 | - | expression tag |
Pro -3 | - | expression tag |
Arg -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Gln 433 | Lys 433 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 120098.1 | |
Non-Polymers* | Number of molecules | 15 |
Total formula weight | 1067.9 | |
All* | Total formula weight | 121166.0 |