6WO5

Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 1a bound to neutralizing antibody 212.1.1 and non neutralizing antibody E1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Fab E1 heavy chain	polymer	227	23938.0	2		Homo sapiens (Human)
2	B, D (B, D)	Fab E1 light chain	polymer	221	24304.0	2		Homo sapiens (Human)
3	E, G (H, G)	Fab 212.1.1 heavy chain	polymer	230	23838.8	2		Homo sapiens (Human)
4	F, H (L, I)	Fab 212.1.1 light chain	polymer	214	23308.9	2		Homo sapiens (Human)
5	I, J (E, F)	Envelope glycoprotein E2	polymer	191	20856.5	2	Pfam (PF01560) UniProt (by SIFTS) (P27958)	Hepatitis C virus (isolate H)
6	K, N (J, N)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
7	L, M (K, M)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
8	O (O)	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	1	In PDB GlyTouCan (G22768VO)
9	P, R, S, T, U (D, E, F)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG)
10	Q (L)	beta-D-mannopyranose	non-polymer		180.2	1	Chemie (BMA)
11	AA, BA, CA, DA, EA... (L, G, I, E, F...)	water	water		18.0	204	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	232492.6
Branched	Number of molecules	5
	Total formula weight	2932.7
Non-Polymers*	Number of molecules	6
	Total formula weight	1286.2
All*	Total formula weight	236711.5

*Water molecules are not included.