6WM4

Human V-ATPase in state 3 with SidK and ADP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	R	V-type proton ATPase 116 kDa subunit a isoform 1	polymer	837	96512.4	1	UniProt (Q93050) Pfam (PF01496) In PDB	Homo sapiens (Human)	V-ATPase 116 kDa isoform a1,Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit,Vacuolar adenosine triphosphatase subunit Ac116,Vacuolar proton pump subunit 1,Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1
2	O	V-type proton ATPase subunit C 1	polymer	382	43999.5	1	UniProt (P21283) Pfam (PF03223) In PDB	Homo sapiens (Human)	V-ATPase subunit C 1,Vacuolar proton pump subunit C 1
3	J, I, H	V-type proton ATPase subunit E 1	polymer	226	26183.3	3	UniProt (P36543) Pfam (PF01991) In PDB	Homo sapiens (Human)	V-ATPase subunit E 1,V-ATPase 31 kDa subunit,p31,Vacuolar proton pump subunit E 1
4	M, L, K	V-type proton ATPase subunit G 1	polymer	118	13781.5	3	UniProt (O75348) Pfam (PF03179) In PDB	Homo sapiens (Human)	V-ATPase subunit G 1,V-ATPase 13 kDa subunit 1,Vacuolar proton pump subunit G 1,Vacuolar proton pump subunit M16
5	S	V-type proton ATPase subunit e 1	polymer	81	9380.3	1	UniProt (O15342) Pfam (PF05493) In PDB	Homo sapiens (Human)	V-ATPase subunit e 1,V-ATPase 9.2 kDa membrane accessory protein,V-ATPase M9.2 subunit,Vacuolar proton pump subunit e 1
6	T	Ribonuclease kappa	polymer	137	15435.2	1	UniProt (Q6P5S7) In PDB	Homo sapiens (Human)	RNase kappa
7	B, C, A	V-type proton ATPase catalytic subunit A	polymer	617	68379.9	3	UniProt (P38606) Pfam (PF02874) Pfam (PF16886) Pfam (PF00006) Pfam (PF22919) In PDB	Homo sapiens (Human)	V-ATPase subunit A,V-ATPase 69 kDa subunit,Vacuolar ATPase isoform VA68,Vacuolar proton pump subunit alpha
8	E, F, D	V-type proton ATPase subunit B, brain isoform	polymer	511	56561.5	3	UniProt (P21281) Pfam (PF00006) Pfam (PF22919) Pfam (PF02874) In PDB	Homo sapiens (Human)	V-ATPase subunit B 2,Endomembrane proton pump 58 kDa subunit,HO57,Vacuolar proton pump subunit B 2
9	Y, Z, X	SidK	polymer	573	65505.3	3	UniProt (A0A4T1L9X6) UniProt (by SIFTS) (Q5ZWW6) In PDB	Legionella pneumophila
10	G	V-type proton ATPase subunit D	polymer	247	28311.9	1	UniProt (Q9Y5K8) Pfam (PF01813) In PDB	Homo sapiens (Human)	V-ATPase subunit D,V-ATPase 28 kDa accessory protein,Vacuolar proton pump subunit D
11	N	V-type proton ATPase subunit F	polymer	119	13388.2	1	UniProt (Q16864) Pfam (PF01990) In PDB	Homo sapiens (Human)	V-ATPase subunit F,V-ATPase 14 kDa subunit,Vacuolar proton pump subunit F
12	U	V-type proton ATPase subunit S1	polymer	470	52067.5	1	UniProt (Q15904) Pfam (PF05827) Pfam (PF20520) In PDB	Homo sapiens (Human)	V-ATPase subunit S1,Protein XAP-3,V-ATPase Ac45 subunit,V-ATPase S1 accessory protein,Vacuolar proton pump subunit S1
13	V	Renin receptor	polymer	350	39045.9	1	UniProt (O75787) Pfam (PF07850) In PDB	Homo sapiens (Human)	ATPase H(+)-transporting lysosomal accessory protein 2,ATPase H(+)-transporting lysosomal-interacting protein 2,ER-localized type I transmembrane adaptor,Embryonic liver differentiation factor 10,N14F,Renin/prorenin receptor,Vacuolar ATP synthase membrane sector-associated protein M8-9,V-ATPase M8.9 subunit
14	0	V-type proton ATPase 21 kDa proteolipid subunit	polymer	205	21418.2	1	UniProt (Q99437) Pfam (PF00137) In PDB	Homo sapiens (Human)	V-ATPase 21 kDa proteolipid subunit,Vacuolar proton pump 21 kDa proteolipid subunit,hATPL
15	1, 2, 3, 4, 5...	V-type proton ATPase 16 kDa proteolipid subunit	polymer	155	15743.7	9	UniProt (P27449) Pfam (PF00137) In PDB	Homo sapiens (Human)	V-ATPase 16 kDa proteolipid subunit,Vacuolar proton pump 16 kDa proteolipid subunit
16	Q	V-type proton ATPase subunit d 1	polymer	351	40369.9	1	UniProt (P61421) Pfam (PF01992) In PDB	Homo sapiens (Human)	V-ATPase subunit d 1,32 kDa accessory protein,V-ATPase 40 kDa accessory protein,V-ATPase AC39 subunit,p39,Vacuolar proton pump subunit d 1
17	P	V-type proton ATPase subunit H	polymer	483	55949.9	1	UniProt (Q9UI12) Pfam (PF03224) Pfam (PF11698) In PDB	Homo sapiens (Human)	V-ATPase subunit H,Nef-binding protein 1,NBP1,Protein VMA13 homolog,V-ATPase 50/57 kDa subunits,Vacuolar proton pump subunit H,Vacuolar proton pump subunit SFD
18	R, U	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	8	Chemie (NAG)
19	A	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	1	Chemie (ADP)

Contents of the asymmetric unit

Polymers	Number of chains	35
	Total formula weight	1248806.6
Non-Polymers*	Number of molecules	9
	Total formula weight	2196.9
All*	Total formula weight	1251003.5

*Water molecules are not included.