6WM1
Crystal structure of the Grb2 SH2 domain in complex with a tripeptide: Ac-pY-Ac6c-N-phenylpropyl
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, C) | Growth factor receptor-bound protein 2 | polymer | 117 | 13758.5 | 2 | UniProt (P62993) Pfam (PF00017) | Homo sapiens (Human) | Adapter protein GRB2,Protein Ash,SH2/SH3 adapter GRB2 |
| 2 | C, D (B, D) | ACE-PTR-02K-ASN-PRA | polymer | 5 | 643.7 | 2 | synthetic construct | ||
| 3 | E, H (C, D) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 4 | F (C) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 5 | G (C) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | I, J, K, L (A, C, B, D) | water | water | 18.0 | 147 | Chemie (HOH) |
Sequence modifications
A, C: 53 - 163 (UniProt: P62993)
| PDB | External Database | Details |
|---|---|---|
| His 164 | - | expression tag |
| His 165 | - | expression tag |
| His 166 | - | expression tag |
| His 167 | - | expression tag |
| His 168 | - | expression tag |
| His 169 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 28804.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 259.7 | |
| All* | Total formula weight | 29064.1 |
