6WKZ
Cocomplex structure of Deoxyhypusine synthase with inhibitor 6-[(1R)-2-AMINO-1-PHENYLETHYL]-3-(PYRIDIN-3-YL)-4H,5H,6H,7H-THIENO[2,3-C]PYRIDIN-7-ONE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Deoxyhypusine synthase | polymer | 372 | 41213.6 | 2 | UniProt (P49366) Pfam (PF01916) | Homo sapiens (Human) | DHS |
| 2 | C, D (A, B) | 6-[(1R)-2-amino-1-phenylethyl]-3-(pyridin-3-yl)-5,6-dihydrothieno[2,3-c]pyridin-7(4H)-one | non-polymer | 349.4 | 2 | Chemie (8Y1) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 99 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 369 (UniProt: P49366)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 82427.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 698.9 | |
| All* | Total formula weight | 83126.1 |
