6WKQ
1.98 Angstrom Resolution Crystal Structure of NSP16-NSP10 Heterodimer from SARS-CoV-2 in Complex with Sinefungin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | 2'-O-methyltransferase | polymer | 301 | 33627.5 | 2 | UniProt (P0DTD1) Pfam (PF06460) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) | Non-structural protein 16,nsp16,SARS-CoV-2 NSP16 |
| 2 | B, D (B, D) | Non-structural protein 10 | polymer | 142 | 15075.2 | 2 | UniProt (P0DTD1) Pfam (PF09401) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) | nsp10,Growth factor-like peptide,GFL,SARS-CoV-2 NSP10 |
| 3 | E, F, P, Q (A, C) | SODIUM ION | non-polymer | 23.0 | 4 | Chemie (NA) | |||
| 4 | G, R (A, C) | SINEFUNGIN | non-polymer | 381.4 | 2 | Chemie (SFG) | |||
| 5 | AA, H, I, J, K... (C, A) | FORMIC ACID | non-polymer | 46.0 | 15 | Chemie (FMT) | |||
| 6 | BA, CA, N, O (D, B) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 7 | DA, EA, FA, GA (A, B, C, D) | water | water | 18.0 | 636 | Chemie (HOH) |
Sequence modifications
A, C: 6799 - 7096 (UniProt: P0DTD1)
B, D: 4254 - 4392 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| Ser 6796 | - | expression tag |
| Asn 6797 | - | expression tag |
| Ala 6798 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 4251 | - | expression tag |
| Asn 4252 | - | expression tag |
| Ala 4253 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 97405.4 | |
| Non-Polymers* | Number of molecules | 25 |
| Total formula weight | 1806.7 | |
| All* | Total formula weight | 99212.1 |
