6WKQ
1.98 Angstrom Resolution Crystal Structure of NSP16-NSP10 Heterodimer from SARS-CoV-2 in Complex with Sinefungin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | 2'-O-methyltransferase | polymer | 301 | 33627.5 | 2 | UniProt (P0DTD1) Pfam (PF06460) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) | Non-structural protein 16,nsp16,SARS-CoV-2 NSP16 |
| 2 | B, D (B, D) | Non-structural protein 10 | polymer | 142 | 15075.2 | 2 | UniProt (P0DTD1) Pfam (PF09401) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) | nsp10,Growth factor-like peptide,GFL,SARS-CoV-2 NSP10 |
| 3 | E, F, P, Q (A, C) | SODIUM ION | non-polymer | 23.0 | 4 | Chemie (NA) PubChem (923) | |||
| 4 | G, R (A, C) | SINEFUNGIN | non-polymer | 381.4 | 2 | Chemie (SFG) PubChem (176612030) PubChem (177116271) PubChem (25246236) PubChem (46875078) PubChem (46936257) PubChem (70602121) PubChem (456189) PubChem (4065234) PubChem (65482) PubChem (70789212) PubChem (93287274) PubChem (92403972) PubChem (93287270) PubChem (93287272) PubChem (93475589) PubChem (6917665) PubChem (12771338) PubChem (12771337) PubChem (131971033) PubChem (131972810) PubChem (138626357) PubChem (156562738) PubChem (162866891) PubChem (163339130) PubChem (168280605) | |||
| 5 | AA, H, I, J, K... (C, A) | FORMIC ACID | non-polymer | 46.0 | 15 | Chemie (FMT) PubChem (284) | |||
| 6 | BA, CA, N, O (D, B) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 7 | DA, EA, FA, GA (A, B, C, D) | water | water | 18.0 | 636 | Chemie (HOH) |
Sequence modifications
A, C: 6799 - 7096 (UniProt: P0DTD1)
B, D: 4254 - 4392 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| Ser 6796 | - | expression tag |
| Asn 6797 | - | expression tag |
| Ala 6798 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 4251 | - | expression tag |
| Asn 4252 | - | expression tag |
| Ala 4253 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 97405.4 | |
| Non-Polymers* | Number of molecules | 25 |
| Total formula weight | 1806.7 | |
| All* | Total formula weight | 99212.1 |
