6WJ7

The structure of NTMT1 in complex with compound C2A

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B	N-terminal Xaa-Pro-Lys N-methyltransferase 1	polymer	241	27320.1	1	UniProt (Q9BV86) Pfam (PF05891) In PDB	Homo sapiens (human)	Alpha N-terminal protein methyltransferase 1A,Methyltransferase-like protein 11A,N-terminal RCC1 methyltransferase,X-Pro-Lys N-terminal protein methyltransferase 1A,NTM1A
2	A	GLY-PRO-LYS-ARG-ILE-ALA-NH2	polymer	7	640.8	1		synthetic construct
3	A	5'-{[(3S)-3-amino-3-carboxypropyl](ethyl)amino}-5'-deoxyadenosine	non-polymer		395.4	1	Chemie (AN6)
4		water	water		18.0	233	Chemie (HOH)

Sequence modifications

B: 2 - 223 (UniProt: Q9BV86)

PDB	External Database	Details
Met -17	-	expression tag
Gly -16	-	expression tag
Ser -15	-	expression tag
Ser -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
Ser -7	-	expression tag
Ser -6	-	expression tag
Gly -5	-	expression tag
Leu -4	-	expression tag
Val -3	-	expression tag
Pro -2	-	expression tag
Arg -1	-	expression tag
Gly 0	-	expression tag
Ser 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	27960.9
Non-Polymers*	Number of molecules	1
	Total formula weight	395.4
All*	Total formula weight	28356.3

*Water molecules are not included.