6WIV

Structure of human GABA(B) receptor in an inactive state

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Gamma-aminobutyric acid type B receptor subunit 1	polymer	810	91585.9	1	UniProt (Q9UBS5) Pfam (PF01094) Pfam (PF00003)	Homo sapiens (Human)	Gb1
2	B (B)	Gamma-aminobutyric acid type B receptor subunit 2	polymer	827	93278.8	1	UniProt (O75899) Pfam (PF01094) Pfam (PF00003) Pfam (PF18455)	Homo sapiens (Human)	Gb2,G-protein coupled receptor 51,HG20
3	C, D, E, L (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)
4	F (A)	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
5	G (A)	(2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-{[(9Z)-octadec-9-enoyl]oxy}propyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate	non-polymer		766.0	1	Chemie (U3G)
6	H, I, J, K, N... (A, B)	CHOLESTEROL	non-polymer		386.7	10	Chemie (CLR)
7	M (B)	[(2R)-3-[(Z)-icos-11-enoyl]oxy-2-[(Z)-octadec-9-enoyl]oxypropyl] 2-(trimethylazaniumyl)ethyl phosphate	non-polymer		814.2	1	Chemie (U3D)

Sequence modifications

A: 1 - 802 (UniProt: Q9UBS5)

PDB	External Database	Details
Asp 803	-	expression tag
Tyr 804	-	expression tag
Lys 805	-	expression tag
Asp 806	-	expression tag
Asp 807	-	expression tag
Asp 808	-	expression tag
Asp 809	-	expression tag
Lys 810	-	expression tag

B: 1 - 819 (UniProt: O75899)

PDB	External Database	Details
Asp 820	-	expression tag
Tyr 821	-	expression tag
Lys 822	-	expression tag
Asp 823	-	expression tag
Asp 824	-	expression tag
Asp 825	-	expression tag
Asp 826	-	expression tag
Lys 827	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	184864.6
Non-Polymers*	Number of molecules	17
	Total formula weight	6371.7
All*	Total formula weight	191236.3

*Water molecules are not included.