6WHN
Histone deacetylases complex with peptide macrocycles
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Histone deacetylase 2 | polymer | 385 | 43897.9 | 3 | UniProt (Q92769) Pfam (PF00850) | Homo sapiens (Human) | HD2 |
| 2 | D, E, F (F, G, H) | U2M-ASN-PRO-LYS-GLN-DLY-TRP-GLY peptide macrocycle | polymer | 8 | 1017.2 | 3 | synthetic construct | ||
| 3 | G, P, W (A, B, C) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 4 | H, I, Q, R, X... (A, B, C) | SODIUM ION | non-polymer | 23.0 | 6 | Chemie (NA) | |||
| 5 | J, S (A, B) | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID | non-polymer | 207.3 | 2 | Chemie (NHE) | |||
| 6 | AA, K, L, M, U (C, A, B) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 5 | Chemie (PG4) | |||
| 7 | BA, N, T, V, Z (C, A, B) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 5 | Chemie (PGE) | |||
| 8 | O (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 9 | CA, DA, EA, FA, GA... (A, B, C, F, G...) | water | water | 18.0 | 968 | Chemie (HOH) |
Sequence modifications
A, B, C: 6 - 389 (UniProt: Q92769)
| PDB | External Database | Details |
|---|---|---|
| Ala 5 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 134745.5 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 2576.9 | |
| All* | Total formula weight | 137322.3 |
