6WG6

Crystal structure of human SMC1-SMC3 hinge domain heterodimer in north-open conformation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G, I... (A, C, E, G, I...)	Structural maintenance of chromosomes protein	polymer	233	26710.8	6	UniProt (G8JLG1) Pfam (PF06470) UniProt (by SIFTS) (Q14683)	Homo sapiens (Human)
2	B, D, F, H, J... (B, D, F, H, J...)	Structural maintenance of chromosomes protein 3	polymer	256	29422.3	6	UniProt (Q9UQE7) Pfam (PF06470)	Homo sapiens (Human)	SMC-3,Basement membrane-associated chondroitin proteoglycan,Bamacan,Chondroitin sulfate proteoglycan 6,Chromosome-associated polypeptide,hCAP
3	M, N (M, N)	poly(dT)	polymer	10	2997.0	2		Homo sapiens

Sequence modifications

A, C, E, G, I, K: 472 - 702 (UniProt: G8JLG1)

PDB	External Database	Details
Gly 470	-	expression tag
Pro 471	-	expression tag

B, D, F, H, J, L: 465 - 712 (UniProt: Q9UQE7)

PDB	External Database	Details
Gly 457	-	expression tag
Pro 458	-	expression tag
Leu 459	-	expression tag
Gly 460	-	expression tag
Ser 461	-	expression tag
Gly 462	-	expression tag
Arg 463	-	expression tag
Pro 464	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	14
	Total formula weight	342792.8
All*	Total formula weight	342792.8

*Water molecules are not included.