6W89
Structure of DNMT3A (R882H) in complex with CGA DNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, G, I (A, D, G, J) | DNA (cytosine-5)-methyltransferase 3A | polymer | 285 | 32696.7 | 4 | UniProt (Q9Y6K1) Pfam (PF00145) | Homo sapiens (Human) | Dnmt3a,DNA methyltransferase HsaIIIA,M.HsaIIIA |
| 2 | B, D, H, J (B, C, H, I) | DNA (cytosine-5)-methyltransferase 3-like | polymer | 209 | 24163.7 | 4 | UniProt (Q9UJW3) | Homo sapiens (Human) | |
| 3 | E, F, K, L (E, F, K, L) | CGA DNA (25-MER) | polymer | 25 | 7699.0 | 4 | synthetic construct | ||
| 4 | M, O, Q, S (A, D, G, J) | CITRIC ACID | non-polymer | 192.1 | 4 | Chemie (CIT) | |||
| 5 | N, P, R, T (A, D, G, J) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 4 | Chemie (SAH) | |||
| 6 | AA, BA, CA, DA, EA... (G, H, J, I, K...) | water | water | 18.0 | 259 | Chemie (HOH) |
Sequence modifications
A, D, G, J: 628 - 912 (UniProt: Q9Y6K1)
| PDB | External Database | Details |
|---|---|---|
| His 882 | Arg 882 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 258237.4 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2306.1 | |
| All* | Total formula weight | 260543.5 |
