6W5L

2.1 A resolution structure of Norovirus 3CL protease in complex with inhibitor 7g

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	3C-LIKE PROTEASE	polymer	188	20133.1	4	UniProt (Q83883) In PDB	Norwalk virus (strain GI/Human/United States/Norwalk/1968) (Hu/NV/NV/1968/US)
2	A, B, C, D	(2~{S})-~{N}-[(1~{R})-1-[bis($l^{1}-oxidanyl)-methoxy-$l^{5}-sulfanyl]-1-oxidanyl-3-[(3~{R})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]-2-[[[2-(3-chlorophenyl)-2-methyl-propoxy]-oxidanylidene-methyl]amino]-4-methyl-pentanamide	non-polymer		604.1	4	Chemie (T0D)
3		water	water		18.0	81	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 181 (UniProt: Q83883)

PDB	External Database	Details
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	80532.3
Non-Polymers*	Number of molecules	4
	Total formula weight	2416.5
All*	Total formula weight	82948.8

*Water molecules are not included.