6W5J

1.85 A resolution structure of Norovirus 3CL protease in complex with inhibitor 7d

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	3C-LIKE PROTEASE	polymer	187	19994.9	2	UniProt (Q83883) In PDB	Norwalk virus (strain GI/Human/United States/Norwalk/1968) (Hu/NV/NV/1968/US)
2	A, B	2-(3-chlorophenyl)-2-methylpropyl [(2S)-3-cyclohexyl-1-({(1R,2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]-1-sulfanylpropan-2-yl}amino)-1-oxopropan-2-yl]carbamate	non-polymer		554.1	2	Chemie (TKS)
3		water	water		18.0	110	Chemie (HOH)

Sequence modifications

A, B: 1 - 181 (UniProt: Q83883)

PDB	External Database	Details
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	39989.9
Non-Polymers*	Number of molecules	2
	Total formula weight	1108.3
All*	Total formula weight	41098.2

*Water molecules are not included.