6W52

Prefusion RSV F bound by neutralizing antibody RSB1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Fusion glycoprotein F0	polymer	82	9215.4	1	UniProt (P03420) In PDB	Human respiratory syncytial virus A (strain A2)	Protein F
2	B	Fusion glycoprotein F1 fused with Fibritin trimerization domain	polymer	414	45609.1	1	UniProt (A0A2H4WLA4) UniProt (A0A2Z5WL46) Pfam (PF00523) UniProt (by SIFTS) (P03420) UniProt (by SIFTS) (Q76VI8) In PDB	Human respiratory syncytial virus A
3	H	RSB1 Fab Heavy Chain	polymer	283	29977.4	1		Homo sapiens (Human)
4	L	RSB1 Fab Light Chain	polymer	236	25137.0	1		Homo sapiens (Human)

Sequence modifications

A: 26 - 107 (UniProt: P03420)

PDB	External Database	Details
Ala 102	Pro 102	conflict

B: 137 - 513 (UniProt: A0A2H4WLA4)

PDB	External Database	Details
Val 152	Ile 152	conflict
Cys 155	Ser 155	conflict
Phe 190	Ser 190	conflict
Leu 207	Val 207	conflict
Cys 290	Ser 290	conflict
Ser 514	-	linker
Ala 515	-	linker
Ile 516	-	linker
Gly 517	-	linker

B: 518 - 544 (UniProt: A0A2Z5WL46)

PDB	External Database	Details
Gly 545	-	expression tag
Gly 546	-	expression tag
Leu 547	-	expression tag
Val 548	-	expression tag
Pro 549	-	expression tag
Arg 550	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	109939.0
All*	Total formula weight	109939.0

*Water molecules are not included.