6W4G

Hepatitis C virus polymerase NS5B with RO inhibitor for SAR studies

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	NS5B	polymer	568	63249.6	2	UniProt (P26663) Pfam (PF00998) In PDB	Hepatitis C virus genotype 1b (isolate BK) (HCV)	Nonstructural protein 5B
2	A, B	5-[[(2~{S})-4-[1,1-bis(oxidanylidene)-1,2-benzothiazol-3-yl]-2-~{tert}-butyl-3-oxidanyl-5-oxidanylidene-2~{H}-pyrrol-1-yl]methyl]-2-fluoranyl-benzenecarbonitrile	non-polymer		453.5	2	Chemie (SL4)
3		water	water		18.0	404	Chemie (HOH)

Sequence modifications

A, B: 2 - 562 (UniProt: P26663)

PDB	External Database	Details
Met -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	126499.1
Non-Polymers*	Number of molecules	2
	Total formula weight	907.0
All*	Total formula weight	127406.1

*Water molecules are not included.