6W4F
NMR-driven structure of KRAS4B-GDP homodimer on a lipid bilayer nanodisc
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, D) | Apolipoprotein A-I | polymer | 200 | 23234.3 | 2 | UniProt (P02647) Pfam (PF01442) | Homo sapiens (Human) | ApoA-I,Apolipoprotein A1 |
| 2 | C, D (B, C) | GTPase KRas | polymer | 184 | 21043.0 | 2 | UniProt (P01116) Pfam (PF00071) | Homo sapiens (Human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 3 | AA, AC, BA, BC, CA... (D, C, A, B) | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 787.1 | 64 | Chemie (PCW) | |||
| 4 | AB, BB, CB, DB, EB... (D, C, A, B) | O-[(S)-({(2R)-2,3-bis[(9Z)-octadec-9-enoyloxy]propyl}oxy)(hydroxy)phosphoryl]-L-serine | non-polymer | 788.0 | 16 | Chemie (17F) | |||
| 5 | HB, YB (B, C) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) | |||
| 6 | IB, ZB (B, C) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) |
Sequence modifications
A, D: 201 - 398 (UniProt: P02647)
B, C: 2 - 185 (UniProt: P01116)
| PDB | External Database | Details |
|---|---|---|
| Gly 199 | - | expression tag |
| Pro 200 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asp 12 | Gly 12 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 88554.5 | |
| Non-Polymers* | Number of molecules | 84 |
| Total formula weight | 63919.4 | |
| All* | Total formula weight | 152474.0 |
