6W39
Structure of unphosphorylated IRE1 in complex with G-1749
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Serine/threonine-protein kinase/endoribonuclease IRE1 | polymer | 431 | 49303.3 | 2 | UniProt (O75460) Pfam (PF00069) Pfam (PF06479) In PDB | Homo sapiens (Human) | Endoplasmic reticulum-to-nucleus signaling 1,Inositol-requiring protein 1,hIRE1p,Ire1-alpha,IRE1a |
| 2 | A, B | ethyl ~{N}-[6-methyl-5-[3-[2-[[(3~{S})-piperidin-3-yl]amino]pyrimidin-4-yl]pyridin-2-yl]oxy-naphthalen-1-yl]carbamate | non-polymer | 498.6 | 2 | Chemie (SJG) | |||
| 3 | water | water | 18.0 | 388 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 98606.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 997.2 | |
| All* | Total formula weight | 99603.7 |
