6W2X
CryoEM Structure of Inactive GABAB Heterodimer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Gamma-aminobutyric acid type B receptor subunit 1 | polymer | 829 | 94173.6 | 1 | UniProt (Q9UBS5) Pfam (PF01094) Pfam (PF00003) | Homo sapiens (Human) | Gb1 |
| 2 | B (B) | Gamma-aminobutyric acid type B receptor subunit 2 | polymer | 908 | 102799.2 | 1 | UniProt (O75899) Pfam (PF01094) Pfam (PF00003) Pfam (PF18455) | Homo sapiens (Human) | Gb2,G-protein coupled receptor 51,HG20 |
| 3 | C, D (C, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 4 | E, F (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 5 | G, J (A, B) | (1S)-2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate | non-polymer | 746.0 | 2 | Chemie (L9Q) | |||
| 6 | H (A) | [(2~{S})-3-[[(1~{S})-1-(3,4-dichlorophenyl)ethyl]amino]-2-oxidanyl-propyl]-(phenylmethyl)phosphinic acid | non-polymer | 402.3 | 1 | Chemie (SGG) | |||
| 7 | I (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) |
Sequence modifications
A: 30 - 844 (UniProt: Q9UBS5)
B: 42 - 941 (UniProt: O75899)
| PDB | External Database | Details |
|---|---|---|
| Asp 22 | - | expression tag |
| Tyr 23 | - | expression tag |
| Lys 24 | - | expression tag |
| Asp 25 | - | expression tag |
| Asp 26 | - | expression tag |
| Asp 27 | - | expression tag |
| Asp 28 | - | expression tag |
| Lys 29 | - | expression tag |
| His 845 | - | expression tag |
| His 846 | - | expression tag |
| His 847 | - | expression tag |
| His 848 | - | expression tag |
| His 849 | - | expression tag |
| His 850 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asp 34 | - | expression tag |
| Tyr 35 | - | expression tag |
| Lys 36 | - | expression tag |
| Asp 37 | - | expression tag |
| Asp 38 | - | expression tag |
| Asp 39 | - | expression tag |
| Asp 40 | - | expression tag |
| Lys 41 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 196972.7 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 848.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2361.1 | |
| All* | Total formula weight | 200182.6 |
