6W16

Crystal structure of a human metapneumovirus monomeric fusion protein complexed with 458 Fab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (F)	Fusion glycoprotein F0,Envelope glycoprotein fusion	polymer	539	59100.0	1	UniProt (Q6W8S4) UniProt (M1E1E4) Pfam (PF00523) Pfam (PF07921)	Human metapneumovirus
2	B (H)	458 Fab heavy chain	polymer	219	23316.2	1		Homo sapiens (Human)
3	C (L)	458 Fab light chain	polymer	214	23586.2	1		Homo sapiens (Human)
4	D (A)	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	1	In PDB GlyTouCan (G22768VO)
5	E (F)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)

Sequence modifications

F: 1 - 105 (UniProt: Q6W8S4)
F: 112 - 489 (UniProt: Q6W8S4)

PDB	External Database	Details
Lys 106	-	linker
Lys 107	-	linker
Arg 108	-	linker
Lys 109	-	linker
Arg 110	-	linker
Arg 111	-	linker
Ser 490	-	linker
Gly 491	-	linker
Arg 492	-	linker
Glu 493	-	linker
Asn 494	-	linker
Leu 495	-	linker
Tyr 496	-	linker
Phe 497	-	linker
Gln 498	-	linker
Gly 499	-	linker
Gly 500	-	linker
Gly 501	-	linker
Gly 502	-	linker
Gly 503	-	linker
Ser 504	-	linker

F: 505 - 532 (UniProt: M1E1E4)

PDB	External Database	Details
Gly 533	-	expression tag
Thr 534	-	expression tag
Glu 535	-	expression tag
Gly 536	-	expression tag
Arg 537	-	expression tag
His 538	-	expression tag
His 539	-	expression tag
His 540	-	expression tag
His 541	-	expression tag
His 542	-	expression tag
His 543	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	106002.4
Branched	Number of molecules	1
	Total formula weight	910.8
Non-Polymers*	Number of molecules	1
	Total formula weight	221.2
All*	Total formula weight	107134.4

*Water molecules are not included.