6W09
Human mAbs broadly protect against infection of arthritiogenic alphaviruses by recognizing conserved elements of the MXR8 receptor binding domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | E1 glycoprotein | polymer | 393 | 42721.2 | 4 | UniProt (Q88628) Pfam (PF01589) | Chikungunya virus (CHIKV) | |
| 2 | E, F, G, H (E, F, G, H) | E2 glycoprotein | polymer | 338 | 38266.3 | 4 | UniProt (Q88628) Pfam (PF00943) | Chikungunya virus (CHIKV) | |
| 3 | I, K, M, O (I, J, K, L) | Fab CHK-265 heavy chain | polymer | 218 | 23743.7 | 4 | Homo sapiens (Human) | ||
| 4 | J, L, N, P (M, N, O, P) | Fab CHK-265 light chain | polymer | 211 | 22888.4 | 4 | Homo sapiens (Human) | ||
| 5 | Q, R, S, T (Q, R, S, T) | E3 | polymer | 60 | 6904.1 | 4 | UniProt (Q88628) Pfam (PF01563) | Chikungunya virus (CHIKV) |
Sequence modifications
E, F, G, H: 1 - 338 (UniProt: Q88628)
| PDB | External Database | Details |
|---|---|---|
| Ser 114 | Gly 443 | conflict |
| Gly 115 | Arg 444 | conflict |
| Arg 144 | Gly 473 | conflict |
| Lys 145 | Arg 474 | conflict |
| Val 313 | Ile 642 | conflict |
| Ile 314 | Arg 643 | conflict |
| Arg 315 | Leu 644 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 20 |
| Total formula weight | 538094.7 | |
| All* | Total formula weight | 538094.7 |
