6W07
Bruton's tyrosine kinase in complex with compound 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Tyrosine-protein kinase BTK | polymer | 293 | 33896.9 | 1 | UniProt (Q06187) Pfam (PF07714) In PDB | Homo sapiens (Human) | Agammaglobulinemia tyrosine kinase,ATK,B-cell progenitor kinase,BPK,Bruton tyrosine kinase |
| 2 | A | ~{N}-[[2-methyl-4-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]phenyl]methyl]-3-propan-2-yloxy-azetidine-1-carboxamide | non-polymer | 435.5 | 1 | Chemie (S9A) | |||
| 3 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 4 | water | water | 18.0 | 262 | Chemie (HOH) |
Sequence modifications
A: 371 - 659 (UniProt: Q06187)
| PDB | External Database | Details |
|---|---|---|
| Gly 367 | - | expression tag |
| Pro 368 | - | expression tag |
| Leu 369 | - | expression tag |
| Gly 370 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33896.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 513.7 | |
| All* | Total formula weight | 34410.5 |
