6VW1

Structure of SARS-CoV-2 chimeric receptor-binding domain complexed with its receptor human ACE2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Angiotensin-converting enzyme 2	polymer	597	69153.7	2	UniProt (Q9BYF1) Pfam (PF01401)	Homo sapiens (Human)	ACE-related carboxypeptidase,Angiotensin-converting enzyme homolog,ACEH,Metalloprotease MPROT15
2	C, D (E, F)	SARS-CoV-2 chimeric RBD	polymer	217	24329.5	2	UniProt (P59594) UniProt (P0DTC2) Pfam (PF09408)	Human SARS coronavirus (SARS-CoV)	S glycoprotein,E2,Peplomer protein
3	E, F, L (C, D, L)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	3	In PDB GlyTouCan (G15407YE)
4	G, H, I, K, M (G, H, I, K, M)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	5	In PDB GlyTouCan (G42666HT)
5	J (J)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		789.7	1	In PDB GlyTouCan (G25906YW)
6	N, R (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
7	O, S (A, B)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
8	P, T, U, V (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	4	Chemie (EDO)
9	Q, W, X (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)
10	AA, BA, Y, Z (E, F, A, B)	water	water		18.0	26	Chemie (HOH)

Sequence modifications

E, F: 319 - 454 (UniProt: P59594)
E, F: 455 - 518 (UniProt: P0DTC2)
E, F: 519 - 535 (UniProt: P59594)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	186966.3
Branched	Number of molecules	9
	Total formula weight	4671.4
Non-Polymers*	Number of molecules	11
	Total formula weight	1113.6
All*	Total formula weight	192751.2

*Water molecules are not included.