6VUR
Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT366
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | N-acetyltransferase Eis | polymer | 422 | 45999.1 | 1 | UniProt (P9WFK7) Pfam (PF13527) Pfam (PF17668) Pfam (PF13530) In PDB | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | Aminoglycoside N-acetyltransferase,Enhanced intracellular survival protein,Protein-lysine N-acetyltransferase |
2 | A | 2-({[(3S)-1-methylpiperidin-3-yl]methyl}sulfanyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amine | non-polymer | 348.5 | 1 | Chemie (ROG) | |||
3 | A | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
4 | A | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
5 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
6 | A | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
7 | A | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
8 | water | water | 18.0 | 195 | Chemie (HOH) |
Sequence modifications
A: 1 - 402 (UniProt: P9WFK7)
PDB | External Database | Details |
---|---|---|
Met -19 | - | expression tag |
Gly -18 | - | expression tag |
Ser -17 | - | expression tag |
Ser -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
Ser -9 | - | expression tag |
Ser -8 | - | expression tag |
Gly -7 | - | expression tag |
Leu -6 | - | expression tag |
Val -5 | - | expression tag |
Pro -4 | - | expression tag |
Arg -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
His 0 | - | expression tag |
Ala 204 | Cys 204 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 45999.1 | |
Non-Polymers* | Number of molecules | 14 |
Total formula weight | 1277.6 | |
All* | Total formula weight | 47276.7 |